Why Is the Additional (Ring)nitrogen in Tryptophan Not Very Basic

question 11

Multiple Choice

Why is the additional (ring) nitrogen in tryptophan not very basic?

• A) Cyclic amines are not basic.
• B) It is too far from the carboxyl group to be effected.
• C) Aromatic amines are weakly basic because of resonance.
• D) The additional amine group is offset by an additional carboxylic acid group.
• E) It is sp² hybridized as therefore not as basic.

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