ZC Is a 49-Year-Old Man with Autosomal Dominant Polycystic Kidney

question 11

Multiple Choice

Z.C. is a 49-year-old man with autosomal dominant polycystic kidney disease (ADPKD) . His kidneys are enlarged with multiple urine-filled cystic lesions. Z.C. is currently in a stage of renal insufficiency with a GFR of about 20% of normal. He suffers from recurrent urinary tract infections and chronic anemia. In counseling Z.C. about the risk of transmitting the disorder to his offspring, which of the following statements would be correct?

• A) Each offspring has a 50% chance of developing the disease.
• B) Each offspring has a 25% chance of developing the disease.
• C) Each offspring has a 50% chance of being a carrier.
• D) Only boys are affected, whereas girls are carriers.

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