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Exhibit 16-6
To answer the following question(s),refer to the data below:
Isobutylbenzene is the starting material for the industrial synthesis of the NSAID,ibuprofen.
-Refer to Exhibit 16-6.Attempts to prepare isobutylbenzene by direct Friedel-Crafts alkylation of benzene result in tert-butylbenzene as the major product.Write the complete stepwise mechanism for this reaction,showing all electron flow with arrows and showing all intermediate structures.
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