Find the minimum cost solution for the transportation problem detailed in the table below. 
Before your solution can be implemented, you discover that the combination Source 3 - Destination 1 is unavailable, due to political turmoil in the country where Source 3 is located. Solve the revised problem. How much is cost increased by this complication?
Definitions:
Neural
Pertaining to the nerves or the nervous system.
Autocrine
Relating to or denoting a mode of hormone action where a hormone affects the same cell type that produced it.
Nuclear Receptor
A class of proteins within cells that, upon binding with a ligand, can act as transcription factors to regulate gene expression.
G Protein
A type of protein that acts as a molecular switch inside cells, involved in transmitting signals from stimuli outside the cell to its interior.
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