Tay Sachs Disease Is Caused by a Recessive Mutation on Chromosome

question 56

Multiple Choice

Tay Sachs disease is caused by a recessive mutation on chromosome 15,and 1 of every 27 members of the Old Order Amish community of Pennsylvania carry a recessive allele.What is the chance that an Old Order Amish man who carries the allele will have a child with Tay Sachs? (Remember,the community restricts marriage to other members of the community. )

• A) 1/4 (25%)chance
• B) 1/27 (3.7%)chance
• C) 100% chance
• D) 1/27 × 1/4 (0.926%)chance
• E) 1/2 (50%)chance

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