Match the Cofactors Below with Their Roles in the Pyruvate

question 66

Essay

Match the cofactors below with their roles in the pyruvate dehydrogenase complex reaction.
Cofactors:
A. Coenzyme A (CoA-SH)
B. NAD⁺
C. Thiamine pyrophosphate (TPP)
D. FAD
E. Lipoic acid in oxidized form
Roles:
_______ Attacks and attaches to the central carbon in pyruvate
_______ Oxidizes FADH₂
_______ Accepts the acetyl group from reduced lipoic acid
_______ Oxidizes the reduced form of lipoic acid
_______ Initial electron acceptor in oxidation of pyruvate.

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