George Cunningham Was Diagnosed with Crohn's Disease When 23 Years

question 67

Multiple Choice

George Cunningham was diagnosed with Crohn's disease when 23 years old.He was experiencing acute abdominal pain,diarrhea,rectal bleeding,anemia and weight loss.He did not respond to conventional immunosuppressive therapies and was given a course of infliximab,an anti-TNF-α monoclonal antibody that suppresses inflammation by blocking TNF-α activity.On day 12 after receiving his first infusion,he developed a mild fever,generalized vasculitis,swollen lymph glands,swollen joints and joint pain.Traces of blood and protein were detected in his urine.Which of the following is the most likely cause of these recent symptoms?

• A)Type I hypersensitivity involving anaphylaxis.
• B)Type II hypersensitivity leading to hemolytic anemia.
• C)Type III hypersensitivity caused by immune complex deposition in blood vessels.
• D)Type IV hypersensitivity involving CD8 T-cell cytotoxicity.
• E)Type II hypersensitivity leading to thrombocytopenia.

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