The Disadvantage of Having a Longer Hinge Region in IgG3

question 15

Multiple Choice

The disadvantage of having a longer hinge region in IgG3 compared with the other IgG subclasses is a reduction in its serum half-life because of its susceptibility to _____.

• A)increased proteolysis by serum proteases
• B)clearance by erythrocytes via FcR binding
• C)immune complex formation and deposition in kidney glomeruli
• D)complement fixation and uptake by cells bearing receptor CR1
• E)opsonization by neutrophils.

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