Which of the Following Statements About Notch 1 Is Correct

question 22

Multiple Choice

Which of the following statements about Notch 1 is correct? (Select all that apply.)

• A)Notch 1 is expressed on thymic epithelial cells.
• B)In the absence of Notch 1 expression,T cells can complete their differentiation.
• C)Notch 1 is to T-cell development as Pax-5 is to B-cell development.
• D)Notch 1 contains two distinct domains,one of which is proteolytically cleaved and becomes a transcription factor in the nucleus.
• E)The extracellular domain of Notch 1 must interact with a ligand on thymic epithelium to initiate cleavage and separation of the Notch 1 extracellular and intracellular domains.

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