Large Pre-B Cells Undergo Clonal Expansion Before the Rearrangement of Light-Chain

question 17

Multiple Choice

Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci.Which of the following are beneficial consequences of clonal expansion? (Select all that apply.)

• A)Autoreactive B cells are eliminated before the expenditure of energy needed to rearrange a functional light-chain gene.
• B)The energy used to make a functional heavy chain is not wasted as a result of the inability to produce a functional light chain.
• C)RAG gene expression is decreased,which in turn signals light-chain rearrangement.
• D)A diverse population of immature B cells is generated that express the same μ chain but a distinct light chain.
• E)Approximately 85% of small pre-B cells will progress to the immature B-cell stage.

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