When Producing Monoclonal Antibodies,why Is It Important to Use as a Fusion

question 5

Multiple Choice

When producing monoclonal antibodies,why is it important to use as a fusion partner a myeloma cell that is unable to produce its own immunoglobulin?

• A)to ensure that allelic exclusion of μ chain occurs normally
• B)to ensure that the antibodies are homogeneous and able to make strong bivalent attachments to multivalent antigens
• C)to ensure that the monoclonal antibodies are not autoreactive
• D)to provide a greater opportunity for making a successful rearrangement at the light-chain locus
• E)to ensure that antibodies are secreted and not membrane-bound.

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