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AWhat Are the Two Main Checkpoints of B-Cell Development in the Bone

question 41

Essay

A.What are the two main checkpoints of B-cell development in the bone marrow?
B.What is the fate of developing B cells that produce (i)functional or (ii)nonfunctional heavy and light chains?
C.Explain how these two checkpoints correlate with the process of allelic exclusion that ensures that only one heavy-chain locus and one light-chain locus produce functional gene products.


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