What Is the Role of Primary Lymphoid Follicles in Eliminating

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The Answer is To survive,circulating B cells must enter primary follicles where survival signals are delivered by cells in the follicles,including follicular dendritic cells (which are the stromal cells of primary lymphoid follicles).Circulating B cells that fail to enter follicles in secondary lymphoid tissues will die in the peripheral circulation with a half-life of about 3 days.B cells with antigen receptors specific for soluble self antigen are generally rendered anergic in the bone marrow or the circulation.Anergic B cells that enter secondary lymphoid organs are held in the T-cell areas adjacent to primary follicles and are not permitted to penetrate the follicle.As a result,they do not receive the necessary stimulatory signal for survival.Instead,anergic B cells will undergo apoptosis in the T-cell zone.This is an efficient cleansing mechanism and serves to delete potentially autoreactive B cells from the circulation.

What Is the Role of Primary Lymphoid Follicles in Eliminating

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