If Viewing the Three-Dimensional Structure of a T-Cell Receptor from the Side,with

question 73

Multiple Choice

If viewing the three-dimensional structure of a T-cell receptor from the side,with the T-cell membrane at the bottom and the receptor pointing upwards,which of the following is inconsistent with experimental data?

• A)The highly variable CDR loops are located across the top surface.
• B)The membrane-proximal domains consist of C_α and C_β.
• C)The portion that makes physical contact with the ligand comprises V_β and C_β,the domains farthest from the T-cell membrane.
• D)The transmembrane regions span the plasma membrane of the T cell.
• E)The cytoplasmic tails of the T-cell receptor α and β chains are very short.

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