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Trisomy 21,or Down Syndrome,occurs When There Is a Normal Diploid

question 45

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Trisomy 21,or Down syndrome,occurs when there is a normal diploid chromosomal complement but one extra) chromosome 21.Although fertility is reduced in both sexes,females have higher fertility rates than males.Van Dyke et al.1995; Down Syndrome Research and Practice 32 : 65-69 summarize data involving children born of Down syndrome individuals.Assume that children are born to a female with Down syndrome and a normal 46- chromosome male.What proportion of the offspring would be expected to have Down syndrome?

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Definitions:

Validity Error

A discrepancy or mistake that affects the accuracy or truthfulness of a test's results.

Content Validity

The extent to which a test or measure represents all facets of a given construct or domain.

Given Construct

A given construct refers to a specific concept or theoretical idea that is established and used as a basis for research or analysis.

Content Validity Ratio

A ratio of the number of raters who evaluate an item and the number of raters who deem an item to be an essential component of the construct being measured.

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