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Trisomy 21,or Down Syndrome,occurs When There Is a Normal Diploid

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Trisomy 21,or Down syndrome,occurs when there is a normal diploid chromosomal complement but one extra) chromosome 21.While there is reduced fertility in both sexes,females have higher fertility than males.Van Dyke et al.1995; Down Syndrome Research and Practice 32 : 65- 69 summarize data involving children born of Down syndrome individuals.Given the fact that conceptuses with 48 chromosomes four #21 chromosomes are not likely to survive early development,what percentage of surviving offspring would be expected to have Down syndrome if both parents have Down syndrome?

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Definitions:

Simple Random Sample

A segment of a statistical group where every member possesses an identical probability of selection.

Sampling Plan

A strategy that outlines how samples will be collected from a population for the purpose of research or quality control.

Sampling Distribution

The probability distribution of a given statistic based on a random sample, often used to infer about the population.

Standard Deviation

A quantification of the extent to which a group of values is varied or dispersed.

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