Traditional Therapy in APL Includes Pharmacological Concentration of Retinoic Acid

question 9

Multiple Choice

Traditional therapy in APL includes pharmacological concentration of retinoic acid (ATRA) and chemotherapy. What is the function of the chemotherapy component in this treatment protocol?

• A) Induces maturation of the promyelocytes to mature granulocytes
• B) Binds with the target PML/RARA gene and represses gene transcription
• C) Eradicates the leukemic stem cells
• D) Induces cytolysis of the malignant promyelocytes

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