Propose a mechanism for the following transformation. 
Definitions:
Heterozygous
Possessing unlike alleles for a particular trait.
Down Syndrome
A genetic disorder caused by the presence of an extra 21st chromosome, leading to developmental and physical changes.
Disjunction
The separation of chromosomes or sister chromatids during cell division, leading to the distribution of genetic material into daughter cells.
Chromosome 21
One of the 23 pairs of human chromosomes, an extra copy of which is associated with Down syndrome.
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