Why Is an Amide Less Reactive to Nucleophilic Acyl Substitution

question 28

Multiple Choice

Why is an amide less reactive to nucleophilic acyl substitution than an acid chloride?

• A)Nitrogen is a better leaving group.
• B)Chloride is a better leaving group.
• C)Nitrogen donates more electron density into the carbonyl.
• D)The amide anion is less basic.

---

Definitions:

Minor

A person under the age at which they legally become an adult, often less than 18 years old.

Disaffirm

The legal right to renounce or void a contract or agreement, especially in cases involving minors or misrepresentation.

Existence

The state or fact of living, being present, or being real.

Mentally Incompetent Persons

Individuals who are legally recognized as unable to make certain types of decisions for themselves due to mental disability or illness.