Why Is an Amide Less Reactive to Nucleophilic Acyl Substitution

question 28

Multiple Choice

Why is an amide less reactive to nucleophilic acyl substitution than an acid chloride?

• A)Nitrogen is a better leaving group.
• B)Chloride is a better leaving group.
• C)Nitrogen donates more electron density into the carbonyl.
• D)The amide anion is less basic.

---

Definitions:

Common Drivers

Fundamental factors or forces that influence the performance or direction of a process, system, or market.

Facilitators

Individuals or technologies that make a process easier or more achievable, often used in the context of meetings, workshops, or technology implementations.

Supply Chain Relationships

The interactions and partnerships between various parties in the supply chain, including suppliers, manufacturers, and retailers, aimed at optimizing efficiency and service.

Strategic Alliance

A formal arrangement between two or more parties to pursue a set of agreed-upon objectives while remaining independent organizations.