You Are Studying an Individual with Very Low Levels of Insulin

question 77

Multiple Choice

You are studying an individual with very low levels of insulin in her blood.Further analysis indicates that cells of her pancreas are producing normal levels of this protein,but it is accumulating in the cytoplasm rather than being secreted from the cells.Which hypothesis makes the most sense to explain this observation?

• A)A small deletion has removed the nucleotides that code for the signal sequence at the amino terminus of the protein.
• B)A missense mutation has caused premature termination during translation of this protein.
• C)A chromosomal segment that includes the gene for insulin has been inverted.
• D)A two-base deletion near the middle of the gene has altered the reading frame during translation of the protein.
• E)A missense mutation has altered the ribosome-binding sequence at the 5' end of the mRNA.

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Definitions:

Pathophysiology

The examination of abnormal bodily functions linked to illness or injury.

Exocytosis

A cellular process that moves materials within the cell to the outside.

Homeostasis

Maintenance of a constant or static condition of internal environment.

Internal Environment

Refers to the conditions and processes within an organism or organization that contribute to its functioning.