A Current Problem in Modern Medicine Is the Development of Drug

question 46

Multiple Choice

A current problem in modern medicine is the development of drug resistance mutations.This occurs when a mutation arises in a disease-causing microbe making it resistant to a drug and thus rendering the drug useless in treating a specific disease.Many useful drugs are competitive inhibitors of specific enzymes,and the drug-resistance mutations prevent the binding of the drug.These types of mutations,in addition to preventing competitive inhibitor binding,can also sometimes reduce the activity of the enzyme.Why is that the case?

• A)Binding to the competitive inhibitor is essential for the function of the enzyme
• B)These mutations most likely affect an allosteric site on the enzyme
• C)These mutations lower the activation energy of the reaction catalyzed by the enzyme
• D)These mutations most likely change the shape of the active site of the enzyme

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