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When the substrate is bound to the enzyme,the shape of the enzyme may change slightly,leading to
Holy Roman Emperor
The ruler of the Holy Roman Empire, a political entity in Central Europe from the 9th to the 19th century, not directly analogous to the ancient Roman Empire.
Industrial Revolution
A period of major industrialization from the late 18th to mid-19th century that transformed mainly agrarian, rural societies in Europe and America into industrialized, urban ones.
Inflation
The rate at which the general level of prices for goods and services is rising, eroding purchasing power.
Nobles of the Robe
French nobility who earned their titles through holding certain judicial or administrative offices, as opposed to "Nobles of the Sword" who inherited their titles through lineage.
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