Norethindrone Is a Synthetic Steroid That Is Better Than Progesterone

question 9

Multiple Choice

Norethindrone is a synthetic steroid that is better than progesterone in suppressing ovulation.What reagents (1-3) are required to convert norethindrone to the derivatives shown below?

• A)(1)H₂,Pd-C; (2)(CH₃)₂CHCH₂NH₂,NaBH₃CN; (3)a.O₃,b.Zn,DMS
• B)(1)H₂,Pd-C; (2)(CH₃)₂CHCH₂NH₂,mild acid; (3)a.O₃,b.Zn,DMS
• C)(1)a.LiAlH₄,b.H₂O; (2)(CH₃)₂CHCH₂NH₂,NaBH₃CN; (3)a.OsO₄,b.NaHSO₃
• D)(1)a.LiAlH₄,b.H₂O; (2)(CH₃)₂CHCH₂NH₂,mild acid; (3)a.OsO₄,b.NaHSO₃

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