Using the Example of Genes Encoding Cytochrome P450 Enzymes, Illustrate

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The Answer is Probably, the best example of copy number variation for genes encoding drug-metabolizing enzymes comes from the CYP2D6 locus on chromosome 22 where the number of gene copies can range from 0 to 13. People who lack both CYP2D6 alleles or who have a deletion of one CYP2D6 allele and an inactivating mutation in the other allele are poor metabolizers for the drugs that this enzyme normally handles. Those who have a solitary CYP2D6 allele that has a reduced function are intermediate metabolizers. Some individuals have many CYP2D6 genes and are ultrafast metabolizers.

Using the Example of Genes Encoding Cytochrome P450 Enzymes, Illustrate

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