How Can a Missense Mutation with a Dominant-Negative Effect Result

question 33

Essay

How can a missense mutation with a dominant-negative effect result in greater loss of protein function and more severe disease than a full length gene deletion at the same gene locus?

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Definitions:

Deductible Contribution

A contribution to a qualified plan or account that is eligible to be deducted from the contributor's gross income for tax purposes.

Nonprofit Cemetery

A burial ground operated by an organization that does not seek to make a profit, often eligible for certain tax exemptions.

Schedule A

The section of the tax form 1040 used by taxpayers to itemize deductions.

Itemized Deductions

Specific expenses that taxpayers can report in order to decrease their taxable income, as opposed to taking a standard deduction.