The Pathogenesis Of $\alpha$ ₁-Antitrypsin Deficiency Due to the Common Missense Mutants PI*S and Missense

question 42

Essay

The pathogenesis of $\alpha$ ₁-antitrypsin deficiency due to the common missense mutants PI*S and PI*Z is due to a failure in protein processing and secretion, and to aberrant protein aggregation. Explain how.

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Definitions:

Dorsal Amygdala

The section of the amygdala responsible for maternal approach behaviors in children and adolescent humans.

Flavor Aversion Learning

A rapid form of learning where an individual learns to avoid a food after a single adverse experience associated with that food.

Central Role

A position of primary importance or function within a system, process, or organization.

Amygdala

A part of the brain involved in experiencing emotions, particularly fear and pleasure, and in forming emotional memories.