With Reference to Imprinting Disorders, Which, If Any, of the Following

question 30

Multiple Choice

With reference to imprinting disorders, which, if any, of the following statements is false?

• A) About one quarter of individuals with Angelman syndrome lack a paternal chromosome 15.
• B) With the exception of abnormal chromosome segregation, imprinting disorders always result from a deletion or inactivating mutation within, or spanning the imprinted gene cluster.
• C) In some imprinting disorders, disease results from inappropriate biallelic expression of a gene.
• D) Angelman and Prader-Willi syndrome are very different disorders but can be caused by precisely the same large deletion at 15q11-q13.

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