Although the Number of Major Histocompatibility MHC) Protein Isoforms Possible

question 12

Multiple Choice

Although the number of major histocompatibility MHC) protein isoforms possible in a given human population is enormous, why does each individual have a limited array of MHC molecules?

• A) because once a B cell has matured in the bone marrow, it is limited to two MHC response categories
• B) because each of the MHC genes has a large number of alleles, but each individual inherits only two for each gene
• C) because once a T cell has matured in the thymus, it can only respond to two MHC categories
• D) because the MHC proteins are made from several different gene regions that are capable of rearranging in a number of ways
• E) because the MHC proteins from one individual can only be of class I or class II

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