How Would an Increase in Ca²⁺ be Expected to Affect

question 42

Multiple Choice

How would an increase in Ca²⁺ be expected to affect the pyruvate dehydrogenase reaction?

• A) The pyruvate dehydrogenase kinase enzyme activity would increase, resulting in an inhibition of pyruvate dehydrogenase activity.
• B) The last step of the pyruvate dehydrogenase reaction is blocked, resulting in a decrease in activity.
• C) The E1 subunit is phosphorylated by pyruvate dehydrogenase kinase, and the catalytic activity of pyruvate dehydrogenase decreases.
• D) The pyruvate dehydrogenase phosphatase-1 enzyme would increase, resulting in pyruvate dehydrogenase activation at an accelerated rate.

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