A Mutation of Lys₂₂₉ in Aldolase Leads to a Loss

question 2

Multiple Choice

A mutation of Lys₂₂₉ in aldolase leads to a loss of enzyme activity.This is most likely because the

• A) active site can no longer exclude water.
• B) active site can no longer include water.
• C) enzyme can no longer hold the intermediate in the correct orientation for catalysis.
• D) product will remain bound to the enzyme active site.

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