The Glutamate Side Chain in the Active Site of HMG-CoA

question 12

Multiple Choice

The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after

• A) the mevalonate binds to the active site.
• B) the hydride from the second NADPH attacks the carbonyl center of the aldehyde.
• C) a conformational change triggers the exchange of NADP⁺ for NADPH.
• D) CoA is reduced to CoA-SH.

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Definitions:

Collagen Fibers

Structural proteins in connective tissues, providing strength, elasticity, and support to skin, bones, cartilage, and blood vessels.

Osteoclast

A type of bone cell that breaks down bone tissue, important for bone maintenance, repair, and remodeling.

Precursor Cells

Cells that have the capacity to differentiate into more specialized cells, often referred to as stem cells.

Osteoblast

A type of cell responsible for bone formation, playing a crucial role in bone growth and repair.