A Mutation in The $\beta$ Subunit of Hemoglobin Is Discovered That Reduces the Affinity of That

question 79

Multiple Choice

A mutation in the $\beta$ subunit of hemoglobin is discovered that reduces the affinity of 2,3-BPG binding. Which of the following mutations is most likely to have this consequence?

• A) Val1 \(\rightarrow\) Ile1
• B) Asp99 \(\rightarrow\) Glu99
• C) Lys82 \(\rightarrow\) Asp82
• D) Glu6 \(\rightarrow\) Val6

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Definitions:

One-Tailed Test

A statistical hypothesis test in which the region of rejection is on only one side of the sampling distribution, testing for a direction-specific hypothesis.

Directional Hypothesis

A hypothesis that specifies the direction of the expected difference or relationship between two variables.

Critical Value

A threshold in hypothesis testing that determines the boundary for rejecting or failing to reject the null hypothesis.

Critical Value

A point on the scale of the test statistic beyond which we reject the null hypothesis; it marks the threshold of statistical significance.