Fetal and Adult Hemoglobin Have Different Affinities for 2,3-BPG $\gamma$ Subunit of the Fetal Red Blood Cells Have a Ser143

question 69

Essay

Fetal and adult hemoglobin have different affinities for 2,3-BPG. Predict if O₂ transport from maternal cells to fetal cells will be altered from the normal rate if the $\gamma$ subunit of the fetal red blood cells have a Ser143 $\rightarrow$ His143 mutation. Include the term T state in your answer.

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