Garrod Hypothesized That Inherited Diseases Such as Alkaptonuria,the Inability to Metabolize

question 65

Multiple Choice

Garrod hypothesized that inherited diseases such as alkaptonuria,the inability to metabolize the chemical alkapton,occur because

• A)metabolic enzymes require vitamin cofactors,and affected individuals have significant nutritional deficiencies.
• B)many metabolic enzymes use DNA as a cofactor,and affected individuals have mutations that prevent their enzymes from interacting efficiently with DNA.
• C)certain metabolic reactions are carried out by ribozymes,and affected individuals lack key splicing factors.
• D)genes dictate the production of specific enzymes,and affected individuals have genetic defects that cause them to lack certain enzymes.

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