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The Deamination of Cytosine Generates a Uracil Base

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The deamination of cytosine generates a uracil base.This is a naturally occurring nucleic acid base, and so does not represent a DNA lesion caused by damage due to chemicals or irradiation.Why is this base recognized as "foreign" and why is it important for cells to have a mechanism to recognize and remove uracil when it is found in the DNA duplex?


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