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You Are Interested in Examining the Psf Gene \quad \quad

question 18

Multiple Choice

You are interested in examining the Psf gene.It is known that Psf is normally produced when cells are exposed to high levels of both calcium (Ca2+) and magnesium (Mg2+) .MetA, MetB, and MetC are important for binding to the promoter of the Psf gene and are involved in regulating its transcription.MetA binds to the "A" site in the promoter region, MetB to the "B" site, and MetC to the "C" site.You create binding-site mutations in the A, B, and C sites and observe what happens to transcription of the Psf gene.Your results are summarized in Table 8-12. \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad \quad  Transcription in the presence of Ca2+ and/or Mg2+\underline{\text { Transcription in the presence of } \mathrm{Ca}^{2+} \text { and/or } \mathrm{Mg}^{2+}}
 Binding sites present  No Ca2+ or Mg2+ With Ca2+ With Mg2+ With Ca2+ and Mg2 A, B, and C ++ none  A only ++ B only  C only ++ A and B only + A and C only ++++ B and C only +\begin{array}{lcccc}\text { Binding sites present } & \begin{array}{l}\text { No } \mathrm{Ca}^{2+} \\\text { or } \mathrm{Mg}^{2+}\end{array} & \begin{array}{l}\text { With } \\\mathrm{Ca}^{2+}\end{array} & \begin{array}{l}\text { With } \\\mathrm{Mg}^{2+}\end{array} & \begin{array}{l}\text { With } \mathrm{Ca}^{2+} \\\text { and } \mathrm{Mg}^{2 *}\end{array} \\\hline \text { A, B, and C } & - & - & - & ++ \\\hline \text { none } & - & - & - & - \\\hline \text { A only } & - & - & + & + \\\hline \text { B only } & - & - & - & - \\\hline \text { C only } & - & + & - & + \\\hline \text { A and B only } & - & - & - & + \\\hline \text { A and C only } & - & + & + & ++ \\\hline \text { B and C only } & - & - & - & +\end{array}

For this table: -= no transcription of Pst,\text {For this table: -= no transcription of Pst,}
+= low level of transcription of Psf, and\text {\( += \) low level of transcription of Psf, and}
++= high levels of transcription of Pst.\text {\( ++= \) high levels of transcription of Pst.}

Table 8-12
Which transcription regulator(s) are normally bound to the Psf promoter in the presence of Mg2+ only?

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Psychologically Disordered

Referring to a pattern of behavioral or psychological symptoms that impact multiple areas of life and create distress for the person affected.

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Bipolar Disorder

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