A Group of Membrane Proteins Can Be Extracted from Membranes

question 56

Multiple Choice

A group of membrane proteins can be extracted from membranes only by using detergents.All the proteins in this group have a similar amino acid sequence at their C-terminus: -KKKKKXXC (where K stands for lysine, X stands for any amino acid, and C stands for cysteine) .This sequence is essential for their attachment to the membrane.What is the most likely way in which the C-terminal sequence attaches these proteins to the membrane?

• A)The cysteine residue is covalently attached to a membrane lipid.
• B)The peptide spans the membrane as an α helix.
• C)The peptide spans the membrane as part of a β sheet.
• D)The positively charged lysine residues interact with an acidic integral membrane protein.

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