You Are Working in a Biotech Company That Has Discovered

question 19

Multiple Choice

You are working in a biotech company that has discovered a small-molecule drug called H5434.H5434 binds to LDL receptors when they are bound to cholesterol.H5434 binding does not alter the conformation of the LDL receptor's intracellular domain.Interestingly, in vitro experiments demonstrate that addition of H5434 increases the affinity of LDL for cholesterol and prevents cholesterol from dissociating from the LDL receptor even in acidic conditions.Which of the following is a reasonable prediction of what may happen when you add H5434 to cells?

• A)Cytosolic cholesterol levels will remain unchanged relative to normal cells.
• B)Cytosolic cholesterol levels will decrease relative to normal cells.
• C)The LDL receptor will remain on the plasma membrane.
• D)The uncoating of vesicles will not occur.

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