Acetylcholine Binds to a GPCR on Heart Muscle, Making the Heart

question 20

Multiple Choice

Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly.The activated receptor stimulates a G protein, which opens a K⁺ channel in the plasma membrane, as shown in Figure 16-13.Which of the following would enhance this effect of the acetylcholine? Figure 16-13

• A)addition of a high concentration of a nonhydrolyzable analog of GTP
• B)addition of a drug that prevents the α subunit from exchanging GDP for GTP
• C)mutations in the acetylcholine receptor that weaken the interaction between the receptor and acetylcholine
• D)mutations in the acetylcholine receptor that weaken the interaction between the receptor and the G protein

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