In the Budding Yeast, Activation of the GTP-Binding Protein Cdc42

question 4

Essay

In the budding yeast, activation of the GTP-binding protein Cdc42 occurs on binding of an external signal (pheromone) to a G-protein-coupled receptor.Activation of Cdc42 promotes actin polymerization.Predict what would happen to actin polymerization, in comparison with pheromone-treated cells, in the following cases.
A.You add pheromone to an inhibitor of G-protein-coupled receptors.
B.You add pheromone to a nonhydrolyzable analog of GTP.

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