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Metabolic Tolerance
An adaptive process where increased metabolic activity reduces the effective concentration of a substance, such as a drug, requiring higher doses to achieve the same effect.
Synaptic Fatigue
A temporary decrease in synaptic efficacy after sustained activity, often resulting from the depletion of neurotransmitter supplies.
Cellular Tolerance
Cellular tolerance is a physiological adaptation where increased exposure to a substance, like a drug, leads to a decrease in the substance's effect on cells or tissues.
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