A Patient Complains of Excessive Urine Output and Constant Thirst

question 17

Multiple Choice

A patient complains of excessive urine output and constant thirst. Laboratory tests show an elevated plasma sodium concentration (151 mEq/L) and elevated plasma osmolality (320 mOsm/L) . The urine osmolality is only 75 mOsm/L. Which of the following could explain the patient's problem?

• A) Defective epithelial sodium channel (ENaC)
• B) Defective ROMK proteins
• C) Defective V₂ receptor proteins
• D) Excessive antidiuretic hormone (ADH) secretion
• E) Defective atrial natriuretic peptide (ANP) secretion

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