Lidocaine, a Use-Dependent Blocker of Voltage-Gated Na⁺ Channels, Is an Effective

question 8

Multiple Choice

Lidocaine, a use-dependent blocker of voltage-gated Na⁺ channels, is an effective antiarrhythmic because its blocking effect becomes greater when:

• A) The drug is repeatedly used.
• B) Na⁺ channels are activated repeatedly at a high frequency.
• C) Na⁺ channels are activated repeatedly at a low frequency.
• D) Na⁺ channels are closed.
• E) The extracellular Na⁺ concentration is high.

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Definitions:

Withdrawing

The act of pulling back or removing oneself from participation in an activity or interaction.

Do Not Disturb Sign

A notice displayed to request privacy or indicate that interruptions are unwelcome at that time, often used in hotels.

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A condition of slow blood flow in the veins, typically in the legs, which can lead to swelling, pain, and complications like varicose veins or venous ulcers.

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