The Problem Below Relates to the Synthesis of Several Intermediates

question 43

Essay

The problem below relates to the synthesis of several intermediates in the citric acid cycle, which is essential in the production of ATP through aerobic respiration. A set of experimental results relating the growth (+) of Neurospora on several media is given in the table. Based on the information provided, present the biochemical pathway for the substances oxaloacetate, fumarate, malate, and succinate, and the locations of the metabolic blocks produced by the various strains. $$\begin{array} { l c c c c c } \text { Strain } & \text { MM } & \begin{array} { c } \text { MM } \\\text { + oxaloacetate }\end{array} & \begin{array} { c } \text { MMedium } \\\text { Mumarate }\end{array} & \begin{array} { c } \text { MM } \\+ \text { malate }\end{array} & \begin{array} { c } \text { MM } \\+ \text { succinate }\end{array} \\\hline 162 & - & + & - & + & - \\136 & - & + & - & - & - \\141 & - & + & + & + & -\end{array}$$

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Definitions:

Grain-Producing Nation

A country whose agriculture sector significantly contributes to the production of grains such as wheat, corn, and rice.

Airplanes

Aircraft that are powered by one or more engines, capable of flight and used for transportation, military, or recreational purposes.

Automobiles

Vehicles equipped with an engine, primarily used for passenger transportation on roads.

United States

A country located in North America, comprising 50 states and a federal district, known for its significant influence in global economic, political, and cultural matters.