Which of the Following Is Not a Strategy for the Synthesis

question 73

Multiple Choice

Which of the following is not a strategy for the synthesis of polypeptides?

• A) Protect the a-amino group of the amino acid aa1 to reduce its nucleophilicity so that the group does not participate in nucleophilic addition to the carboxyl group of either aa1 or aa2.
• B) Cleave the polypeptide at specific peptide bonds, determine the sequence of each fragment, and then match overlapping fragments to arrive at the sequence of the polypeptide.
• C) Activate the a-carboxyl group of the amino acid aa1 so that the group is susceptible to nucleophilic attack by the a-amino group of aa2.
• D) Protect the a-carboxyl group of the amino acid aa2 so that the amino acid is not susceptible to nucleophilic attack by the a-amino group of another molecule of aa2.

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Definitions:

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The total amount of cash received from the sale of goods, asset disposals, or financing transactions.

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