Provide a Brief Explanation, Based on Features of the Molecules

question 55

Essay

Provide a brief explanation, based on features of the molecules, for the following trend in pK_a values?
CH₃CH₂OH > CF₃CH₂OH
ethanol 2,2,2-trifluoromethanol
15.9 12.4

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Definitions:

Selective Serotonin Reuptake Inhibitors

A class of drugs commonly used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and some personality disorders.

Fragile X Syndrome

A genetic disorder causing intellectual disability, behavioral challenges, and characteristic physical features.

Phenylketonuria

A rare inherited disorder that increases the levels of a substance called phenylalanine in the blood, leading to intellectual disability and other health issues unless managed by diet from an early age.

Phenylalanine

An essential amino acid found in the human body used by the body to produce proteins and other important molecules, which is obtained through the diet.