Which of the Following Experiments Demonstrates That PrP^C Is Required

question 23

Multiple Choice

Which of the following experiments demonstrates that PrP^C is required for prion disease transmission?

• A)Mice with the hamster PrP gene are susceptible to hamster prions.
• B)Mice lacking the Prp gene are resistant to prion infections.
• C)Yeast have proteins that can form self-propagating states like prion proteins.
• D)The PrP^Sc protein has the same amino acid sequence as the PrP^C protein.
• E)Injection of brain extracts from kuru patients into monkeys causes the monkeys to get a similar disease.

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