Which of the Following Experiments Demonstrates That PrP^C Is Required

question 23

Multiple Choice

Which of the following experiments demonstrates that PrP^C is required for prion disease transmission?

• A)Mice with the hamster PrP gene are susceptible to hamster prions.
• B)Mice lacking the Prp gene are resistant to prion infections.
• C)Yeast have proteins that can form self-propagating states like prion proteins.
• D)The PrP^Sc protein has the same amino acid sequence as the PrP^C protein.
• E)Injection of brain extracts from kuru patients into monkeys causes the monkeys to get a similar disease.

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Definitions:

Tay-Sachs Disease

A genetic disorder caused by the absence of a specific enzyme, leading to the accumulation of fatty substances in the brain and nervous system, resulting in deterioration and death.

Genetic Testing

The analysis of DNA, RNA, chromosomes, proteins, and certain metabolites in order to detect heritable disease-related genotypes, mutations, phenotypes, or karyotypes for clinical purposes.

Carriers

Individuals or organisms that have one copy of a recessive gene for a genetic trait or disease but do not exhibit the trait or disease themselves.

Reciprocal Translocations

A chromosome abnormality caused by exchange of segments between non-homologous chromosomes.