Binding of the Large T Antigen of SV40 to the Cellular

question 8

Multiple Choice

Binding of the large T antigen of SV40 to the cellular protein pRb causes which of the following to occur?

• A) Degradation of the cellular protein p53
• B) Activation of the apoptosis pathway.
• C) Replication of viral DNA
• D) Dissociation of the transcription factor E2F.
• E) Blocks progression through the cell cycle.

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